These molecules are expressed in different eye diseases, and diabetic retinopathy; the predominant DAMPs are S100, HMGB1, uric acid, HSPs, ATP, cyclophilin A, Aβ, IL 1-α, IL-33, nuclear DNA, mtROS, formyl peptide, and lipid from the mitochondrial membrane [92]. Here, HMGB1 is linked to eye disorder.