Adiponectin knock-out mice were under a Se-enhanced diet, which contained 0.75 ppm (200 μg per day) of added Se for 194 days; chronic inflammation-induced colon cancer (CICC) was initiated with the colon cancer agent 1,2 dimethyl hydrazine (DMH) along with dextran sodium sulphate (DSS). This evidence concerns the gene ADIPOQ and colonic neoplasm.