It is also noted that SELENOP mRNA expression might be related to some immune functions, as it was positively correlated with immune marker genes for macrophage subtypes, including tumour-associated macrophages (CD80, CD86 and HLA-G), M1 macrophages (CD36, IL-6 and NOS2), and M2 macrophages (TGFβ, STAT6 and IL-10) in the following cancers: kidney clear cell carcinoma, brain lower grade glioma, lung adenocarcinoma and skin cutaneous melanoma [123]. The gene discussed is IL6; the disease is cancer.