Adiponectin knock-out mice were under a Se-enhanced diet, which contained 0.75 ppm (200 μg per day) of added Se for 194 days; chronic inflammation-induced colon cancer (CICC) was initiated with the colon cancer agent 1,2 dimethyl hydrazine (DMH) along with dextran sodium sulphate (DSS). This evidence concerns the gene ADIPOQ and malignant colon neoplasm.