HK2 and cancer: Because the mitochondria of cancer cells are markedly different from those of normal cells, there are a variety of potential mitochondrial targets [21], for example, mitochondrial membrane potential (ΔΨm), mitochondrial protein import machinery, hexokinase 2 (HK2), ion channels, ROS inducer, mitochondrial autophagy inducer, mtDNA, electron transport chain, etc. Glycyrrhetinic acid can interact with mitochondrial ETC, resulting in decreased mitochondrial membrane potential.