A genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF) in a large European ancestry sample failed to find any significant associations between these genes and schizophrenia [79]. This evidence concerns the gene AKT1 and schizophrenia.