CHRNA7 and Alzheimer disease: What is known is that Aβ1–42 and α7nAChR appear within AD neuritic plaques, and that Aβ1–42 selectively binds with high affinity to α7nAChR to form α7nAChR-Aβ1–42 complexes, but reductions in the α7nAChR and Aβ1–42 interaction may not effectively halt the disease progression in AD.