Interestingly, children with different types of PFIC display a different spectrum of symptoms: failure to thrive is common in PFIC1, elevated ALT is common in PFIC2 (BSEP deficiency), and thrombocytopenia is common in PFIC3 (MDR3 deficiency) [16]. Here, ABCB4 is linked to hyperinsulinemic hypoglycemia, familial, 4.