BCL2 and neoplasm: Moreover, Au-Ag NPs are also involved in intrinsic pathways’ induced apoptosis of tumor cells, and the BCL2 family controls the permeability of mitochondrial membrane [47]; PDA-coated branched Au-Ag NPs decreased the BCL2 level, which further led to the depolarization of mitochondrial membrane potential (ΔΨm) and the subsequent release of cytochrome c into the cytoplasmic matrix.