The study conducted on B16F10 melanoma tumor-bearing mice showed that, compared with the untreated animal, the tumor volume and weight declined by ~80% after treatment with a dose of 264 μg of STAT3 siRNA, while the tumor weight and volume reduced by ~50% after treatment with a dose of 132 μg of STAT3 siRNA. The gene discussed is STAT3; the disease is neoplasm.