DOHH and cancer: CPX could inhibit the certain iron-dependent enzymes, such as ribonucleotide reductase, deoxyhypusine hydroxylase and prolyl 4-hydroxylase, as well as blocking the Wnt/β-catenin and mTORC1 signaling pathways through iron-related chelation, which will lead to proliferation inhibition and cell death in cancer cells [30,31].