In the past decade, TM4SF1 was demonstrated to be expressed and involved in the progression of different cancers, including prostate cancer (PRC) [27], pancreatic cancer (PC) [31], ovarian cancer (OC), breast cancer (BC) [13,50], CRC, and gastric cancer (GC) [51,52]. Here, TM4SF1 is linked to pachyonychia congenita.