In this regard, Li et al. [102] also showed that EMT biomarkers, such as TGF-β, TNF-α, and NF-κB, as well as the transcriptional factors (e.g., Snail and PI3K), were involved in the integrated pathways (e.g., TGF-β/Snail or TNF-α/ NF-κB) of TM4SF4 to facilitate EMT process and CRC prognosis. The gene discussed is TNF; the disease is colorectal carcinoma.