EGFR and carcinoma of esophagus: In addition to these compounds, genistein, a predominant isoflavonoid commonly originating from legumes and dentate plants, was suggested to have the ability to block the Janus-activated kinase 1/2 (JAK1/2)-signal transduction and the signal transducer and activator of transcription 3 (STAT3) signaling pathways in esophageal carcinoma cells by suppressing the expression of epidermal growth factor receptor (EGFR), which finally leads to the inhibition of cell proliferation and cell cycle arrest [46].