Inspired by the acid tumor microenvironments, the C-X-C chemokine receptor 4 (CXCR4) is overexpressed in Rb, and the elevated concentration of cellular glutathione, the CXCR4 antagonist (AMD11070) and DOX loaded, glycol chitosan-coated ceria nanoparticles (GCCNPs) were constructed by Gao et al. to treat the Rb [112]. The gene discussed is CXCR4; the disease is neoplasm.