Therefore, this study aimed to (1) determine the best extraction solvent for optimal antimelanoma activity compared to current anticancer drugs, (2) investigate the effect of the extracts on the expression of genes involved in BRAF/MEK and TNFR1/NF-kB induced cell death pathways in melanoma cells, and (3) to evaluate responsible proteins and peptides in these extracts. The gene discussed is TNFRSF1A; the disease is melanoma.