NFE2L2 and melanoma: In the D24 melanoma cells, cytotoxicity was strongly correlated with NF-kB (0.99, p < 0.001), MEK1 (0.81, p < 0.001) and Nrf2 (r = 0.79, p < 0.001) expression, indicated by the clustered grouping in the left quadrat (Figure 8A).