NFE2L2 and melanoma: In the MM418-C1 melanoma cells, cytotoxicity had a strong positive correlation with mRNA expression of MEK1 (0.90, p < 0.001), BRAFV600E (0.89, p < 0.001), NF-kB (r = 0.85, p < 0.001) and Nrf2 (r = 0.79, p < 0.001), as seen clustered together in the left quadrat (Figure 8B).