Conversely, the interaction between vascular endothelial growth factor receptor 2 (VEGFR-2) and VEGF will activate signaling cascades (PI3K/Akt and p38MAPK) that affect many cellular functions, such as migration, survival, vascular permeability, and the proliferation of cancer tissue cells, and, hence, trigger angiogenesis [9]. This evidence concerns the gene KDR and cancer.