In addition to the AR activity abolishment created by Top2 catalytic inhibitors in PCa genesis, they might also be used to reduce stem gene transcription by inhibiting Top2, as previously demonstrated by ICRF-193 in neuronal ES cells reducing essential genes such as LIN28 and NANOG with the extra function of Top2 inhibitors, thus inducing cell cycle arrest [136]. This evidence concerns the gene TOP2A and posterior cortical atrophy.