TP53 and osteosarcoma: In addition, it was found that allicin could considerably induce oxidative stress and autophagy to suppress osteosarcoma growth via inactivating the MALAT1-miR-376a-Wnt/β-catenin axis, or promote ROS production and p53-dependent autophagy in live cancer, but it is not clear whether autophagy was regulated by ROS [156,184].