Chrysin-treated anaplastic thyroid cancer (ATC) tumors revealed increased protein levels of Notch1 and Hes1 (hairy/enhancer of split 1), and activated Notch1 might induce cleaved Poly ADP ribose polymerase (PARP) protein, indicating that apoptosis could be induced to inhibit cancer cells [193]. This evidence concerns the gene HES1 and thyroid gland undifferentiated (anaplastic) carcinoma.