CD274 and non-small cell lung carcinoma: It has been reported in non-small cell lung cancer (NSCLC) that higher 18F-RGD uptake is associated with low PD-L1 expression in tumor cells, and SUVmax is the best parameter to display tumoral expression of PD-L1, which indicates that 18F-RGD PET may be useful for reflecting the immune status [35].