The role of honokiol includes the induction of apoptosis and autophagy in osteosarcoma cells by ROS/ERK1/2 signaling [30], suppression of pancreatic cancer progression, and invasion by miR-101/Mcl-1 and SMAD2/3 axis [27,43], reduction of gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 [44], and antagonism of doxorubicin resistance in breast cancer through miR-188-5p/FBXW7/c-Myc pathway [45]. This evidence concerns the gene SMAD2 and osteosarcoma.