VEGFA and malignant colon neoplasm: In addition to surgery, colon cancer has developed various chemotherapy drugs such as oxaliplatin, 5-fluorouracil, capecitabine, and irinotecan, as well as biological drugs such as bevacizumab, trastuzumab, pertuzumab, and cetuximab, while these antibodies targeting the VEGF and EGFR families have very limited therapeutic efficacy in the advanced colon cancer [36,37].