In NAFLD mice, HU not only improved serum lipid indicators (TC, TG, LDL-C, LDL-C/HDL-C) and liver function parameters (AST, AST/ALT) but also inhibited the abnormal enlargement of epididymal fat cells and massive deposition of lipid in the liver. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.