VEGFA and irritable bowel syndrome: Moreover, the results of the KEGG analysis revealed that 62 pathways might be involved in JM25-1 regulatory action in IBS as shown in Figure 6E, mainly the mTOR signaling pathway, PI3K-AKT signaling pathway, ErbB signaling pathway, VEGF signaling pathway, Rap1 signaling pathway and Ras signaling pathway.