In summary, curcumin can inhibit intestinal pyroptosis through activation of the SIRT1/NRF2 pathway; reduce intestinal tissue secretion of IL-1β, IL-6, IL-18, and TNFα; and attenuate the loss of gastrointestinal barrier proteins ZO-1 and occludin, elucidating that curcumin is dependent on the gut–brain axis and thus exerted neuroprotective effects in the MPTP-induced PD mouse model (Graphical Abstract I). Here, IL18 is linked to Parkinson disease.