The present data together with the Kaizer report indicated that aluminum chloride produced severe cholinergic neuronal dysfunction deficits as well as increased AChE activity and hypothalamic AChE expression, which could explain the brain neurodegeneration [68]; it may then evaluate the effects of oral administration of donepezil (2.5 mg/kg), gallic acid (50 mg/kg), OPE (100 mg/kg), and OPE (200 mg/kg) before aluminum chloride injection on AChE activity and correlate these activities with their anti-AD effect. The gene discussed is ACHE; the disease is Alzheimer disease.