Animal models targeting ASD-associated Shank mutations exhibit ASD-associated behavioural phenotypes, including impaired sociability and communication, enhanced repetitive self-grooming, and anxiety [157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195]. The gene discussed is SHANK2; the disease is Anxiety.