Unlike Shank2 and Shank3 mutant mice, no NMDAR-specific malfunction was observed in Shank1 mutant mice, although these animals displayed behavioural deficits, such as increased anxiety-related behaviours; impaired long-term memory retention and contextual fear memory; reduced motor function; and decreased levels of ultrasonic vocalizations and scent marking [166,181,186]. Here, SHANK2 is linked to Anxiety.