According to a study of an Indian cohort, Vidyant et al. have shown that the non-synonymous polymorphisms Arg753Gln, Arg677Trp, and Pro631His were uncommon, but the TLR2 −196 to −174Ins/Del polymorphism was found to be a risk factor for HIV-1 infection (a mutant genotype and allele TLR2 Del was more frequent in HIV-infected patients) [56]. The gene discussed is TLR2; the disease is HIV-1 infection.