These are promising results for the use of recombinant S. mansoni AK and HGPRT enzymes as vaccine targets to combat schistosomiasis mansoni, and a better understanding of the mechanisms by which these enzymes act to control the disease, as well as the modulation of the inflammatory process regulating both innate and humoral immunity, is needed in this experimental model. The gene discussed is ADK; the disease is Schistosomiasis mansoni.