In this way, the present work proposed to evaluate the effects of immunization with the recombinant S. mansoni enzymes Adenosine Kinase (AK) and Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT) in addition to MIX with the two enzymes in the control of the experimental murine infection to contribute to the search for a candidate vaccine for schistosomiasis. The gene discussed is ADK; the disease is schistosomiasis.