SLC16A3 and cancer: Together with MCT4 and BSG, they facilitate the release of lactate and H+ to the extracellular milieu to neutralize intracellular acidosis in a HIF-1-dependent manner [16], which is associated with a hyperglycolytic and acid-fast phenotype in cancer [14,17,18] and the release of lactate into the extracellular milieu [19].