Using available information [4,5,6,7,8,9,10,11], we defined five micro-environments for analysis (Table S3): mild COVID-19 (CoV-mild) with high levels of IL2e and IL12e; moderate COVID-19 (CoV-mod) with high levels of IFNGe and IL12e; severe COVID-19 (CoV-sev) with high levels IFNGe, IL-12, IL4e, and IL6e; severe COVID-19 with extrinsic TGF-β (CoV-TGFB) with IFNGe, IL-12, IL4e, IL6e, and TGFBe; and severe COVID-19 with extrinsic IL-10 (CoV-IL10) with IFNGe, IL-12, IL4e, IL6e, and IL10e. Here, IL10 is linked to COVID-19.