CD4 and chronic obstructive pulmonary disease: Similarly, SGE treatment reduced the number of airway inflammatory cells from lung tissue that had been increased by COPD induction by CSE/LPS stimulation, including activated T cells (CD4+/CD69+, CD8+/CD69+, CD62L−/CD44high+), B cells (CD21+/B220+), and neutrophils (Gr-1+/SiglecF−) (Table 2, upper rows).