For example, S. nigra berries and flowers have been shown to exert inhibitory activity against ACE2 SARS-CoV-2 RBD binding in vitro [24]; S. nigra berry extract can reduce virus titers in Vero cells infected with infectious bronchitis virus (a pathogenic poultry coronavirus) [23]; Cannabis sativa extract has been found to decrease ACE2 protein levels [64]; and Agathis robusta bark essential oil has shown effectiveness against COVID-19 [20]. The gene discussed is ACE2; the disease is COVID-19.