In this randomized controlled trial (RCT), which included 52 patients with non-diabetic nephropathy, the dietary protein intake assessed through the Maroni formula changed significantly from 1.02 ± 0.04 g/kg/day during angiotensin-converting enzyme (ACE) inhibition and following a regular sodium diet (200 mmol Na+/day) to 0.96 ± 0.04 g/kg/day (p = 0.004) on a low sodium diet (160 mmol Na+/day) [23]. The gene discussed is ACE; the disease is diabetic kidney disease.