SLC22A12 and hyperuricemia: In clinical practice, drugs used to treat hyperuricemia work by inhibiting uric acid synthesis or promoting uric acid excretion, such as allopurinol and febuxostat, which are XOD inhibitors that depress uric acid synthesis [50], in contrast to benzbromarone and probenecid, which promote uric acid excretion by suppressing URAT1 and GLUT9 [51].