PAX6 and Abnormal emotional state: Indeed, DNA methylation at CpG4 was positively related to interpersonal alienation (IA) (rho = 0.636; p < 0.05) and emotional dysregulation (ED) (rho = 0.798; p < 0.01) and CpG6 with ED (rho = 0.830; p < 0.001) in the AN1 group.