Previous studies showed that the sea cucumber triterpene glycoside Frondoside A induces the apoptosis through regulation of several pro-apoptotic factors, such as caspase-3, -8, and -9, PARP, Bax, p21, and inhibits autophagy in urothelial carcinoma cells [40]. The gene discussed is CDKN1A; the disease is urothelial carcinoma.