NFKB1 and autoimmune disease: Thymoquinone has also been demonstrated to be hepatoprotective [68], antioxidative [69], neuroprotective due to ischemia [70], antihyperlipidemic [71], nephroprotective [72], immunomodulatory by inhibiting NFkB [73], anti-autoimmune disease agent [74], and anti-cancer [75].