This data was confirmed in a prospective study by Seiler et al, who used a cohort of 312 patients with stage 2–4 CKD after 2.2 follow-up years and found that elevated FGF-23 levels were an independent predictor of death or dialysis (HR 2.49; 95% CI, 1.12–5.54; p = 0.025) [48]. The gene discussed is FGF23; the disease is chronic kidney disease.