In this regard, Lindberg et al generated a mouse model with a-Klotho deleted throughout the nephron and demonstrated how histologically there was an increase in cell density, loss of differentiation between proximal and distal convoluted tubules, and loss of cuboid epithelium of the Bowman’s capsule associated with interstitial fibrosis and widespread nephrocalcinosis. The gene discussed is KL; the disease is nephrocalcinosis.