Therapeutic drugs may offer a substitute for many symptomatic patients with fibroids who desire a more conservative management approach, with examples of such drugs including NSAIDs, combined oral contraceptives (OCPs), progestins, and levonorgestrel intrauterine system devices (IUDs), and approved (GnRH agonists such as Lupron and antagonists including Elagolix, Relugolix, and Linzagolix) or investigational agents (e.g., selective progesterone receptor modulators (SPRMs)); Mifepristone, Asoprisnil, Telapristone acetate, Ulipristal, and Vilaprisa; somatostatin analogues: Lanreotide. This evidence concerns the gene GNRH1 and leiomyoma.