For example, the ethanol derivative of CUP ameliorated oxidative stress by suppressing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 expression (NOX2) in a chemotherapy-induced neuropathic pain animal model [15] and decreasing the expression levels of pro-inflammatory cytokines, such as interleukin (IL)-6, interferon (IFN)-γ, and tumor necrosis factor-alpha (TNFα), in a type 2 diabetes and systemic inflammation mouse model [18,20]. The gene discussed is TNF; the disease is neuropathic pain.