CFTR and cystic fibrosis: In 2004, Egan et al. published a study on murine models with deltaF508 mutation in the CFTR protein, one of the common CF-associated mutations, concluding that curcumin acting as a SERCA pump inhibitor (sarcoplasmic/endoplasmic reticulum calcium pump inhibitor) could increase the number of functional deltaF508 CFTR, which makes curcumin potentially useful in CF treatment [133].