INS and obesity due to melanocortin 4 receptor deficiency: Our findings of dyslipidemia as a mediator of the relationship between diabetes and obesity in periodontitis are also supported by the results of Adiels et al. [27], which found that liver fat, visceral fat, glucose, insulin, and HOMA-IR index are correlated with the rate of VLDL production using a novel multicompartmental model.