In an investigation that used apoE-knocked out mice fed with a high-fat diet, astaxanthin increased the hepatic levels of LDL receptors, reduced HMG-CoA reductase, and increased Sterol regulatory element-binding protein 2 (SREBP-2), which were associated with hypocholesterolemia effects [63]. This evidence concerns the gene SREBF2 and Hypocholesterolemia.