Our findings show that carriers of the TMEM18 rs939583 and rs1879523 SNPs have a significantly elevated obesity risk (OR = 1.21 95% CI 1.06–1.39; p = 0.002) and for the rs939583 C allele, which has a slightly lower risk (OR = 1.32 [1.10–1.59]) found for Europeans descendants [9]. The gene discussed is TMEM18; the disease is obesity due to melanocortin 4 receptor deficiency.