Salvia officinalis (L.)EO is regarded as one of the most promising natural remedies for AD on the basis of numerous animal studies, in which it showed to enhance memory and cognitive function in rats also by expressing anti AChE activity, to have neuroprotective activity due to boosting the antioxidant defense machinery in vivo, and to have anti-seizure effects [160]. This evidence concerns the gene ACHE and Alzheimer disease.