NFE2L2 and gastric ulcer: Studies have shown that pro-inflammatory cytokines and oxidative homeostasis have a key influence in the onset of gastric ulcer, which sees an overboost of oxidative stress counterbalanced by activation of the nuclear factor-erythroid-2-related factor 2 (Nrf2) signaling pathway, which upregulates the biosynthesis of endogenous antioxidant enzymes [85].