The overexpression of SRD5A2 (p < 0.001) (Figure 4C), PCNA (p < 0.001) (Figure 4D), Bcl-2 (p < 0.001) (Figure 4E), and MMP2 (p < 0.001) (Figure 4F) in the PG tissue of mice with TP-induced BPH was downregulated by treatment with finasteride or SIN. The gene discussed is MMP2; the disease is benign prostatic hyperplasia.