Oral administration of LLF and WLL extracts can significantly inhibit the release of pro-inflammatory mediators (TNFα, IL-6, and IL-1β) in the serum of DN rats, indicating that the anti-inflammatory effects of LLF and WLL extracts may be related to kidney protection in DN; meanwhile, the anti-inflammatory effect of the WLL extract was better than that of the LLF extract. The gene discussed is TNF; the disease is liver dysplastic nodule.