According to Xu et al., curcumin (50 mg/kg) was also effective in reversing the increase in arthritis scores, hind paw edema, and loss of appetite as well as suppressing the inflammatory response by reducing TNF-α, IL-6, and IL-17 and inhibiting the activation of the PI3K/AKT signaling pathway in a mouse CIA model [100]. This evidence concerns the gene TNF and arthritic joint disease.