In a study conducted by Fan et al. in 2018 [106], hyaluronic acid/curcumin (HA/Cur) nanomicelle injected into RA rats reduced edema, friction between cartilage surfaces around joints, and expression of IL-1β, TNF-α, and vascular endothelial growth factor (VEGF). The gene discussed is VEGFA; the disease is rheumatoid arthritis.