CRP and rheumatoid arthritis: In the same way, Amalraj et al. showed that curcumin (250 mg and 500 mg) significantly reduced ESR, CRP, VAS, SJC, TJC, rheumatoid factor (RF) values, DAS28, and American College of Rheumatology (ACR) responses in active RA patients compared to placebo; no side effects were reported [93].