For example, an important coordinating role of NH groups was shown for 2-((1H-benzo[d]imidazol-2-yl)methylthio)-5-methyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (C, Scheme 1) in the binding and inhibition of histone–lysine-specific demethylase 1 (LSD1/KDM1A), involved in the development of cancer cells [12]. The gene discussed is KDM1A; the disease is cancer.