PRKAA2 and breast cancer: When breast cancer cells undergo apoptosis, canonical apoptotic bioregulators, involving the cleavage of caspases, the translocation of Bax to the outer mitochondria membrane, the release of cytochrome-c, and the activation of poly ADP-ribose polymerase (PARP), occur in an orderly manner, which favors AMPK activation [80,83].