ω-hydroxyundec-9-enoic acid (ω-HUA), a secondary plant metabolite, activated AMPK in MCF7, MDA-MB-231 and MDA-MB-435 cells by triggering mitochondrial membrane potential deficiency and promoting the production of ROS, which led to apoptosis in breast cancer cells [243]. The gene discussed is PRKAA1; the disease is breast cancer.