Compound K (C-K, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol), one metabolite of the ginsenosides, was able to activate AMPK in HepG2 hepatoma cells and relieve lipid accumulation by inhibiting SREBP1c and PPARα [234]. Here, PRKAA1 is linked to hepatocellular carcinoma.