Adiponectin is a glycoprotein belonging to the adipokines and the pro-apoptotic effects of adiponectin have been comparatively observed in ERα-negative breast cancer cells, with results indicating the pivotal roles of ER-driven AMPK and other modulators, such as FOXO3a and LKB1 [156,157,158]. This evidence concerns the gene FOXO3 and breast carcinoma.