The depletion of O-linked β-N-acetylglucosamine transferase (OGT) promotes the activation of AMPK via phosphorylation at Thr172, and the activation of AMPK subsequently enhances sterol regulatory element-binding protein 1 (SREBP1) phosphorylation at Ser372, finally impeding FASN and breast cancer growth [130,131]. The gene discussed is PRKAA1; the disease is breast cancer.