Accordingly, statins, which are effective for the reduction in the coronary artery disease risk and for making the plaques more stable, are also found to reduce some ceramide species (Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:1), and Cer(d18:1/24:0)) [25,26,27,28]. This evidence concerns the gene CBLN1 and coronary artery disorder.