The intervention of Phlorizin (MH1) could significantly improve the abnormal levels of glutathione, brain-derived neurotrophic factor, MDA, acetylcholinesterase, extracellular signal-regulated kinase (ERK), tyrosine receptor kinase B (TrkB), and cAMP response element binding protein (CREB) in the brain of diabetes rats, which could effectively improve oxidative stress level and depression in diabetes rats [51,52]. The gene discussed is CREB1; the disease is diabetes mellitus.