EGF and malignant mesothelioma: In malignant mesothelioma SPC212 cells, zymography with fibronectin showed that MMP3 activity was enhanced when treated with various factors such as epidermal growth factor (EGF), transforming growth factor-α (TGF-α), HGF, insulin-like growth factor (IGF)-II, and basic fibroblast growth factor (bFGF) [9].