SLC2A4 and type 2 diabetes mellitus: Limitations of this study include the following aspects: (i) isorhamnetin was administered for a short period of time (ii) GLUT4 expression was assessed using immunoblotting reflective of its total amount, however immunohistochemistry may be a better technique to assess its activity and translocation to the cell membrane, (iii) we only measured GLUT4 expression in the skeletal muscles, this should also be performed using liver and adipose tissue, and (iv) the anti-inflammatory and antioxidant activities of isorhamnetin should be studied more in T2D.