SLC2A4 and type 2 diabetes mellitus: GLUT4 protein expression was significantly downregulated in the presence of T2D (Figure 4A, n = 6, p < 0.05); however, treating diabetic mice with isorhamnetin significantly upregulated GLUT4 expression compared to the vehicle control diabetic group (Figure 4A, n = 6, p < 0.01).